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About Periowave™

Periowave™ uses the powerful photodisinfection reaction to inactivate the bacteria and toxins that are left behind after scaling and root planing.
First, a small quantity of blue-coloured photosensitizer solution is topically applied to the gums at the treatment site where it attaches to microbes and toxins associated with gum disease. Second, a thin, plastic light guide is painlessly placed into the treatment site. The light guide illuminates the treatment site with a specifically calibrated laser light, activating the photosensitizer solution and destroying bacteria beneath the gum line. Each treatment site requires only 60 seconds of laser activation, making it a quick, painless procedure.

To date, Periowave™ has been used in over 75,000 treatments and has been the subject of 5 clinical trials. To learn more, visit

The Periowave™ Advantage

Current therapies for oral-cavity disinfection include antibiotics and antiseptics. Antibiotics must stay uncomfortably in place for long periods of time, frequently resulting in patient non-compliance. Ondine’s Periowave™ treatment can be applied, activated, and then removed from the affected site, maximizing patient comfort. The benefits of this technology include:

  • Rapid action
  • No patient compliance after treatment
  • High specificity to disease-causing bacteria, and
  • Low levels of toxicity to host cells in vitro

Product Development Status

Ondine has obtained a Health Canada License and CE Mark for its Periowave system. It is currently available in Canada and select countries in the European Union.